Influence of promoter/enhancer region haplotypes on MGMT transcriptional regulation: a potential biomarker for human sensitivity to alkylating agents
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منابع مشابه
Differential sensitivity of mouse spermatogenesis to alkylating agents.
ARIOUS alkylating agents have long been used for inducing mutations and Vchromosome breaks in some plants and animals. Effects on Drosophila spermatogenesis have been investigated by AUERBACH (1940, 1949, 1958), especially with mustard gas, and FAHMY and FAHMY (1953, 1956) used various compounds. All types of mutations have so far been obtained-dominant lethals and semilethals, recessive lethal...
متن کاملDNA repair methyltransferase (Mgmt) knockout mice are sensitive to the lethal effects of chemotherapeutic alkylating agents.
We have generated mice deficient in O6-methylguanine DNA methyltransferase activity encoded by the murine Mgmt gene using homologous recombination to delete the region encoding the Mgmt active site cysteine. Tissues from Mgmt null mice displayed very low O6-methylguanine DNA methyltransferase activity, suggesting that Mgmt constitutes the major, if not the only, O6-methylguanine DNA methyltrans...
متن کاملEffect of VKORC1 haplotypes on transcriptional regulation and warfarin dose.
BACKGROUND The management of warfarin therapy is complicated by a wide variation among patients in drug response. Variants in the gene encoding vitamin K epoxide reductase complex 1 (VKORC1) may affect the response to warfarin. METHODS We conducted a retrospective study of European-American patients receiving long-term warfarin maintenance therapy. Multiple linear-regression analysis was used...
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A hypoxic microenvironment induces resistance to alkylating agents by activating targets in the mammalian target of rapamycin (mTOR) pathway. The molecular mechanisms involved in this mTOR-mediated hypoxia-induced chemoresistance, however, are unclear. Here we identify the mTOR target N-myc downstream regulated gene 1 (NDRG1) as a key determinant of resistance toward alkylating chemotherapy, dr...
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Haloalkyl purines i.e. 2,6-diamino-8-(chloromethyl) purine 10; 2, 6-diamino-X- (chloromethyl) purine 17; 2,6-diamino-8-(chloropropylp) urine 18; were synthesized by two distinct but facile methods. The N-alkylating potential of 2, 6-diamino-8- (chloromethyl) purine was investigated. The following products 2,6-diamino-8-(Nbenzyl- N-methyl) purine 11; 2,6-diamino-8-(4-nitro anilinomethyl) pur...
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ژورنال
عنوان ژورنال: Carcinogenesis
سال: 2013
ISSN: 0143-3334,1460-2180
DOI: 10.1093/carcin/bgt355